4-Azidobutanoic acid
4-Azidobutyric acid
CAS: 54447-68-6
Molecular Formula: C4H7N3O2
4-Azidobutanoic acid - Names and Identifiers
| Name | 4-Azidobutyric acid |
| Synonyms | 4-azidobutyric acid 4-Azidobutyric acid 4-Azidobutanoic acid gamma-Azidobutyric acid Butanoic acid, 4-azido- 4-Azidobutyric acid - A1941 |
| CAS | 54447-68-6 |
4-Azidobutanoic acid - Physico-chemical Properties
| Molecular Formula | C4H7N3O2 |
| Molar Mass | 129.11728 |
| Boling Point | 135 °C(Press: 11 Torr) |
| Storage Condition | Room Temprature |
| Sensitive | Irritant, Refrigerate |
| MDL | MFCD11850695 |
4-Azidobutanoic acid - Properties
Open Data Unverified Data
1. Physical properties: 4-Azobutyric acid is a colorless crystalline solid with high melting and boiling points.
2. Chemical properties: 4-Azobutyric acid is a stable compound at room temperature and is also relatively stable in strong acidic or alkaline environments. However, it may explode at high temperatures, pressures, or when reacting with other chemicals.
3. Solubility: 4-Azobutyric acid is soluble in water, alcohols, and other organic solvents, but its solubility is relatively low.
4. Toxicity: 4-Azobutyric acid has certain toxicity and can cause damage to the physiological systems of humans and animals. Excessive exposure or ingestion may cause poisoning.
5. Application: 4-Azobutyric acid is mainly used in organic synthesis reactions, such as as as a raw material for explosive chemicals, dyes, and fluorescent substances. Meanwhile, due to its high hydrophilicity, it can also be used to prepare polymer materials with special properties.
Last Update：2024-04-09 19:43:38
4-Azidobutanoic acid - Application
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1. Fireworks industry: 4-Azobutyric acid is one of the important components in many fireworks and firecracker manufacturing processes. It can serve as an explosive agent, providing the gas required for explosion.
2. Chemical laboratory: 4-Azobutyric acid is commonly used in chemical laboratories for experiments related to explosive chemical reactions or nitrogen release. It can provide nitrogen raw materials and also be used to generate other compounds.
3. Medical research: 4-Azobutyric acid has also played an important role in certain drug research. It can serve as a lead compound for acetylcholinesterase inhibitors, a class of drugs used to treat Alzheimer's disease and other neurological disorders.
4. Industrial chemical production: 4-Azobutyric acid is also used as a raw material or intermediate to produce other organic compounds, such as certain dyes, plastic additives, insecticides, pesticides, etc. Its viscosity and color characteristics make it play an important role in the synthesis of these chemicals.
Last Update：2025-08-19 16:24:40
4-Azidobutanoic acid - Production Method
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1. Preparation of materials:
-Sodium cyanide (NaCN)
-Nitrile (CH3 (CH2) 2CN)
-Sulfuric acid (H2SO4)
-Ammonia water (NH3 · H2O)
-Sodium carbonate (Na2CO3)
-Sodium nitrite (NaNO2)
-Nitric acid (HNO3)
2. Preparation process of azide compounds:
a. Dissolve sodium cyanide in nitrile, add a small amount of sulfuric acid as a catalyst, and undergo cyanide reaction to generate cyanide of nitrile (CH3 (CH2) 2CN2-Na+).
b. Heat and reflux the cyanide solution to react with ammonia water to produce azide acid (CH3 (CH2) 2CN3H) of nitrile.
c. Add the azide acid solution into the sodium nitrite solution in stages to undergo coupling reaction, generating 4-azide butyric acid.
d. Neutralize the salt in the solution with hydrochloric acid or nitric acid, and crystallize and dry the reaction product to obtain pure product.
Attention should be paid to safety during the preparation process. Chemicals such as nitrile and cyanide have certain toxicity. Protective gloves and goggles should be worn during operation, and it should be carried out under well ventilated laboratory conditions. Meanwhile, due to the high explosive sensitivity of azide compounds, careful handling is required during production and storage to avoid conditions that may cause explosions such as impact, friction, and high temperatures.
Last Update：2024-04-09 19:43:38
4-Azidobutanoic acid - Safety
Open Data Unverified Data
1. Toxicity: 4-Azobutyric acid has certain toxicity to human body and environment. It is an irritant and corrosive substance that may cause irritation to the eyes, skin, and respiratory tract. Long term or excessive exposure may pose a threat to human health.
2. Flammability: 4-Azobutyric acid is a combustible substance that may ignite under open flames or high temperatures. Toxic gases and smoke are produced during combustion.
3. Storage and handling: Due to the toxicity and combustibility of 4-azidobutyric acid, appropriate measures should be taken for storage and handling. It should be stored in a dry and well ventilated place, away from ignition sources and flammable materials. When handling 4-azidobutyric acid, appropriate protective equipment should be worn, such as protective goggles, gloves, and respirators.
4. Leakage and accident response: In the event of a leakage or accident, immediate measures should be taken to remove the leaked material and ensure safety. If the leaked solution enters the water source or sewer, the relevant authorities should be notified immediately.
5. First aid measures: If in contact with 4-azidobutyric acid, immediately rinse the affected skin or eyes with plenty of water. If discomfort occurs, seek medical attention immediately.
Please note that the above content only introduces the general safety situation of 4-azidobutyric acid and cannot cover all possible situations of using and handling this compound. Before using or handling 4-azidobutyric acid, please carefully read its MSDS and instructions, and take appropriate safety measures.
Last Update：2024-04-09 19:43:38
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